Guide to Dog Mouth Cancer: What Owners Should Know

Updated June 8, 2022
Cancer beagle

Cancer is a scary word, and if your dog is diagnosed with mouth cancer, you no doubt have many questions. Owners want to know, what the life expectancy of a dog with this disease? What are the symptoms and prognosis? Mouth tumors can cause obstructions that make it difficult for pets to chew and swallow, making it difficult for them to eat and obtain nutrients necessary for wellness. Surgical reduction of growths is often necessary for a dog's survival, but it isn't always possible depending on the tumor's type and location.

Types of Tumors

The good news is that every tumor doesn't automatically blossom into full-blown mouth cancer. Pictures of mouth cancer can help put your mind at ease. According to the Pet Cancer Center, tumors can be divided into two main categories:


Benign tumors are noncancerous growths that, in general, are easily removed by surgical means. These growths are usually well defined at the edges without the type of invasive growth into bones and other tissues that are typically seen with malignant tumors. Benign tumors also don't spread to other parts of the body.

The most common type of benign tumor found in dogs is an epulis. These tumors can be found growing on the periodontal ligament, which is the tissue that attach a dog's teeth to the thick piece of bone that contains the sockets the dog's teeth sit in.


Malignant tumors are cancerous and are usually quite invasive to the area surrounding them. This makes surgical removal difficult, if not impossible. Malignancies also tend to metastasize or "spread" by shedding cells that migrate through the bloodstream to take hold and grow in other areas of the body. Common malignancies include:

  • Malignant melanomas: This type of tumor is the most common mouth cancer in dogs. It is very invasive, and this makes surgical removal quite challenging. It also tends to spread rapidly, so by the time an owner may notice something wrong with her pet, the cancer has probably already spread to other parts of the body. Even if the melanoma is only confined to the mouth area, the tumors can be quite painful for a dog and restrict their ability to eat.
  • Squamous cell carcinomas: These tumors can grow quite aggressively but tend to remain in one localized area without metastasizing.
  • Fibrosarcomas: These tumors are very similar to squamous cell carcinomas in that they tend to resemble a bit of red cauliflower and generally don't metastasize until late in their development.
  • Acanthomatous ameloblastomas: These tumors can be extremely aggressive and cause a lot of destruction in surrounding mouth tissues, but luckily they don't tend to spread.
Mast cell tumor on lip

What Causes Canine Mouth Cancer?

Although it isn't yet possible to determine exactly what spurs the growth of cancerous cells or tumors in a dog's mouth, there are a few theories. It's thought that genetics may play a role in their development, since they're more common in certain breeds of dogs than others. The most common breeds affected with oral tumors include German Shepherds, Boxers, and Golden Retrievers.

Inhaled Carcinogens

Carcinogens are everywhere in our environment and dogs are exposed to them every day. Carcinogens may actually be inhaled by dogs as they sniff the ground and, generally, everything else around them. Cancer-causing agents then have the opportunity to take hold and affect surrounding cells, causing the abnormal cell growth that results in cancer.

Ingested Carcinogens

Dogs may actually consume carcinogens. A research study found a possible link between some commercial dog foods and canine mouth cancer. Some brands actually include chemical preservatives and pesticides in their formulas that may also be carcinogenic, but further study will be required to confirm these early results. Commercial dog food also contains up to 60 percent carbohydrates, resulting in a higher cancer risk.

Detection and Treatment

Early detection is the key to increasing the success rate in the treatment of all mouth cancer in dogs. Sometimes it is already too late to help a pet who is only just beginning to show symptoms of being sick, so it pays to be diligent.

Clinical Signs of Oral Cancer in Dogs

Owners should regularly check their pet's mouth for the following signs:

  • Abnormal lumps or growths inside the mouth
  • Abnormal overgrowth of the gums
  • Bleeding from the mouth or other discharge
  • Presence of sores or white lesions in the mouth
  • Difficulty chewing and/or swallowing
  • Weight loss
  • Pain and tenderness
  • Drooling
  • Bad breath or a foul odor coming from your dog's mouth

Diagnostic Testing for Oral Cancer

In order to make a diagnosis, your veterinarian will do a biopsy of the tumor, as well as perform other tests including blood work and X-rays, CT scans, or ultrasounds. The cost of a biopsy will vary depending on whether your veterinarian can easily do a fine needle aspiration or if surgery is required to get at the tumor to obtain a sample. You can expect to pay from $400 to $1,000 or more for the biopsy.

Stages of Mouth Cancer

There are four stages of oral cancer that are based on guidelines from the World Health Organization.

  1. Stage I has tumors that are 2 centimeters or less in diameter.
  2. Stage II has tumors between 2 and 4 centimeters.
  3. Stage III has tumors that are 4 or more centimeters, or tumors that can be smaller but also include lymph node activity
  4. Stage IV is the point where the tumors spread into other unrelated areas of the body (metastasis).

Canine Mouth Cancer Treatment Options

According to the Pet Cancer Center, treatments for the different types of mouth tumors vary. However, the most effective mouth cancer treatments for dogs include:

  • Surgical removal of tumorous growths
  • Freezing of the tumor material, known as cryosurgery
  • Radiation therapy at the site

Surgery is the most common treatment for oral cancers and is performed by a veterinarian who specializes in oral surgeries. Surgery can involve removing the tumor or part of the jaw that it's attached to and then reconstructing the area surgically. It may also be necessary to remove teeth or gums as well as part of your dog's jaw and cheekbone if they have spread deeper into their mouth.

Radiation therapy uses high-energy beams of radiation to kill cancer cells without harming healthy tissue near them. A machine delivers this treatment directly into affected areas at regular intervals over several weeks until all infected cells are eliminated.

Chemotherapy involves injecting drugs directly into tumors while they're still growing; this allows medications to reach areas that otherwise would be inaccessible through surgery alone.

More aggressive treatments may be supported by holistic therapies, including giving herbal, mineral, and vitamin supplements. Treatment can be expensive with the cost of removing one tumor running from $1,000 to $2,000, plus additional care costs, including blood tests, X-rays, medications, and more.

Melanoma Vaccine

ONCEPT® Melanoma is a vaccine developed by Merial to help increase the life expectancy of dogs during stage II or stage III oral cancer. Unlike a vaccine given to prevent a disease from occurring, ONCEPT is given to dogs diagnosed with oral cancer in order to bolster their body's immunity to cancer cells.

Merial's research has found that the vaccine can extend a dog's life up to one to two years if the dog receives either surgery or radiation treatment, as well. ONCEPT can only be obtained from a veterinary oncologist, and the cost will vary based on your veterinarian's schedule of fees, although you can expect the cost to be in the range of $2,800.

Generalized Life Expectancy

The life expectancy of a dog with oral malignant melanoma largely depends on when it is discovered and treated.

  • If a dog has no medical care, their life expectancy will be approximately two months.
  • If the dog has surgical treatment, the average life expectancy is anywhere from five to 17 months.
  • Dogs given radiation therapy tend to live seven to 12 months.
  • The Merial melanoma vaccine has been found to give dogs a life expectancy of about seven to 13 months. Dogs that have the vaccine, as well as surgery or radiation, have been found to live up to two-and-a-half years after diagnosis.

Dogs with oral squamous cell carcinoma have a very short life expectancy if the tumors are located in the tonsils.

  • Surgery on the tumors on the lower jaw (mandibulectomy) gives an average survival time of 19 to 26 months.
  • Dogs with surgery on the upper jaw (maxillectomy) have an average survival time of 10 to 19 months.
  • Dogs that receive radiation therapy have a survival time of 15 to 16 months, although with surgery this can go up to 34 months.

Are Other Pets at Risk?

If you have other pets in the home, there is no need to worry about the risk of contagion. Cancerous tumors are not infectious and cannot be passed from one pet to another, or to any humans in the household.

Checking Your Dog's Mouth Could Save Their Life

Mouth tumors in dogs are not common, but they do occur. Dogs tend to develop oral tumors much more often than cats do. Mouth tumors in dogs can be benign or malignant, and both types can be life-threatening if left untreated. Checking your dog's mouth for any abnormalities and observing your dog for any abnormal behavior can help you catch tumors early.

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Guide to Dog Mouth Cancer: What Owners Should Know